By Dr. L. W. Poulter, C. Power, C. Hutter, S. Sreenan, C. Burke (auth.), Univ.-Prof. Dr. Friedrich Kummer (eds.)

ISBN-10: 3211824545

ISBN-13: 9783211824542

ISBN-10: 3709175372

ISBN-13: 9783709175378

Das Konzept des allergischen bronchial asthma hat lange Zeit so sehr dominiert, da? die Immunotherapie vielfach ohne gesicherte diagnostische Grundlage, halbherzig oder ohne die Feinheiten der Allergenvermeidung angewendet wurde. Die Forschung der letzten zehn Jahre hat uns eine derartige Ausweitung unseres Wissenshorizontes beschert, da? es an der Zeit schien, ma?gebliche Autoren zur gemeinsamen Diskussion der neuen Aspekte einzuladen. Das Buch berichtet von den neuesten Erkenntnissen uber zellulares Verhalten, unterschiedliche Zytokinmuster und autoimmunologische Aspekte bis hin zur modernen Allergenvermeidung, aber auch von der wirksamen medikamentosen Therapie der eosinophilen Entzundung the concept that of bronchial asthma being an "allergic sickness in basic terms" has ruled above others to an quantity, re-examination of this factor within the mild of very contemporary effects from study in immunopathology appeared greater than past due. This quantity presents a present thought of idea and medical perform of immunopathology and treatment of bronchial asthma, comprising large and fresh laboratory information on atopy, intrinsic bronchial asthma, features of autoimmunology, in addition to directions for allergen avoidance, immunotherapy and - final now not least - pharmacological therapy of eosinophilic irritation.

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Additional resources for Asthma: Immunopathology and Immunotherapy / Immunopathologie und Immunotherapie

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Elastase is an elastolytic enzyme with a broad substrate specificity and will digest most proteins [32, 33]. In particular the possible role of elastase in the development of emphysema has been studied extensively [34]. Proteinase 3 [35] has a broad serine esterase activity and like elastase, proteinase 3 produces emphysema when given intratracheaUy to hamsters [35]. Myeloperoxidase (MPO) is a basic heme-containing protein [36]. The principal function of MPO is that of a strong peroxidase and as such it takes part in the production of short lived and reactive oxygen-derived radicals such as OCI- (hypochlorite) and long-lived radicals such as chloramines [37, 38].

Thromb Res 14: 599-608 16. Gullberg U, Widegren B, Amason U, Egesten A, Olsson I (1986) The cyto· toxic eosinophil cationic protein (ECP) has ribunoclease activity. Biochem Biophys Res Commun 139: 1239-1242 17. Henderson WR, Jorg A, Klebanoff SJ (1982) Eosinophil peroxidase-medi· ated inactivation ofleukotrienes B4, C4 and D4. J Immunol 128: 2609-2613 18. Rohrbach MS, Wheatley CL, Slifman NR, Gleich GJ (1990) Activation of platelets by eosinophil granule proteins. J Exp Med 172: 1271-1274 19. Henderson WR, Chi EY, Klebanoff SJ (1980) Eosinophil peroxidase-in· duced mast cell secretion.

40 C. KroegeJ et al. Eosinophil effector roles in asthma Several observations suggest that the eosinophil is the central effector cell mediating epithelial damage in asthma (Gleich, 1986). , 1990) indicating eosinophil activation and secretion of the granular proteins in the course of the disease. As mentioned herein before, these products possess toxic properties for a whole range of mammalian cells including airway epithelium. For example, MBP alone can cause damage to both guinea pig and human respiratory epithelium mimicking the pathology of asthma.

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Asthma: Immunopathology and Immunotherapy / Immunopathologie und Immunotherapie by Dr. L. W. Poulter, C. Power, C. Hutter, S. Sreenan, C. Burke (auth.), Univ.-Prof. Dr. Friedrich Kummer (eds.)


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