By R. Baserga, L. Kaczmarek, B. Calabretta, R. Battini, S. Ferrari (auth.), Professor Dr. Widmar Tanner, Professor Dr. Dieter Gallwitz (eds.)

ISBN-10: 3642716865

ISBN-13: 9783642716867

ISBN-10: 3642716881

ISBN-13: 9783642716881

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33 Kb - Fig. 4. CDC25 Transcripts in transformed cells. lane a, RNA from exponential growing cells (S288C), lanes b and c, RNA extracted respectively from pDGEm-l and pDGM-4 transformants. The amount of poly(A)+ RNA was 30 ~g for all the lanes. 8 a b c It would be of interest to study transcription also during differentiative pathways, in particular during sporulation, as the CDC25 gene appears to playa role in the sporulation events. Many of the start genes so far cloned from budding yeast and from fission yeast are transcribed in a cell cycle-independent way.

3 kb restriction fragment; this restriction fragment directed the integration of a plasmid containing it to the STE2 locus, demonstrating that the DNA was homologous with the appropriate locus on the genetic map. Furthermore, integration of this sequence restored mating as well as thermo-resistant ligand binding activity to the cell surface. The sequence of the STE2 locus reveals an open reading frame of 431 amino acids (29,30). The most notable feature of the amino acid sequence is the presence of seven hydrophobic domains, each approximately 40 amino acids long, that constitute the amino terminal two thirds of the coding sequence.

C. and L. Hartwell in preparation). A restriction fragment containing the LEU2 substitution of the STE2 gene was cut out of the plasmid and transformed into yeast in order to transplant the STE2 locus with the LEU2 gene. This manipulation will remove the STE2 coding sequence from the genome. Such transformants were obtained and were verified by Southern blot analysis to have the STE2 gene replaced by the LEU2 gene. These transformants were viable, demonstrating that STE2 gene product is not essential for viability.

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Cell Cycle and Oncogenes by R. Baserga, L. Kaczmarek, B. Calabretta, R. Battini, S. Ferrari (auth.), Professor Dr. Widmar Tanner, Professor Dr. Dieter Gallwitz (eds.)


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