By M. De Brabander, M. Mareel and L. De Ridder (Eds.)

ISBN-10: 0080255345

ISBN-13: 9780080255347

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Read or Download Cell Movement and Neoplasia. Proceedings of the Annual Meeting of the Cell Tissue and Organ Culture Study Group, Held at the Janssen Research Foundation, Beerse, Belgium, May 1979 PDF

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Extra resources for Cell Movement and Neoplasia. Proceedings of the Annual Meeting of the Cell Tissue and Organ Culture Study Group, Held at the Janssen Research Foundation, Beerse, Belgium, May 1979

Sample text

It cannot be concluded whether the reorganization is due to the rearrangement of the random microtubules or to the continued centrosomal nucleation accompanied by disintegration of the random m i c r o tubules . Interphase PTK2 cells have a delicate interphase microtubule network (Fig. 5 ) . This is however much more resistant to nocodazole than in MO-cells. Even with 10 yg/ml some cells still contain a small dot which is shown at the ultrastructural level to consist of the centrosome surrounded by short microtubules.

Continuing polymerization in a dynamic equilibrium fashion results thus in the separation of the two asters. The tendency of the two sets of interdigitating microtubules to associate laterally probably aids in the formation of the premetaphase spindle. The inclusion of the chromosomes in the spindle would be ascertained by at least two factors. First, relative cell rounding, which is a rather general event in cells with open spindles, ensures adequate contact. Second, during prometaphase the k i n e tochores ripen and start to nucleate.

W. Kirschner ( 1 9 7 9 ) . Cell, 16, 239-252. A. ( 1 9 7 4 ) . Imrrunocy to chemistry. Englewood, New Jersey: Prentice-Hall. , M . J . L. Rosenbaum" (1975) . Proc. Natl. Acad. Sci. USA, 72, 4023-4027. Essay of Characterization of Skin Fibroblasts derived from Patients with Mammary Tumours. II - Biological Properties of Cell Cultures from Different Body Sites B. Azzarone, M. Mareel* and A. G. (INSERM U50), 94800 'Clinic for Radiotherapy Villejuif, France and Nuclear Medicine, Ghent, Belgium ABSTRACT We compared the growth properties of two skin fibroblastic cultures obtained from different body sites of a patient with breast cancer.

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Cell Movement and Neoplasia. Proceedings of the Annual Meeting of the Cell Tissue and Organ Culture Study Group, Held at the Janssen Research Foundation, Beerse, Belgium, May 1979 by M. De Brabander, M. Mareel and L. De Ridder (Eds.)


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