By Satyajit Sarker, Lutfun Nahar

ISBN-10: 0470017805

ISBN-13: 9780470017807

"This booklet has succeeded in protecting the elemental chemistry necessities required by means of the pharmaceutical technology student… the undergraduate reader, be they chemist, biologist or pharmacist will locate this an engaging and worthy read." –Journal of Chemical Biology, may well 2009

Chemistry for Pharmacy Students is a student-friendly creation to the most important components of chemistry required by way of all pharmacy and pharmaceutical technological know-how scholars. The ebook presents a entire assessment of many of the components of normal, organic items chemistry (in relation to drug molecules).

Clearly dependent to reinforce scholar realizing, the publication is split into six transparent sections. The ebook opens with an outline of normal points of chemistry and their value to fashionable lifestyles, with specific emphasis on medicinal purposes. The textual content then strikes directly to a dialogue of the strategies of atomic constitution and bonding and the basics of stereochemistry and their importance to pharmacy- when it comes to drug motion and toxicity. numerous features of aliphatic, fragrant and heterocyclic chemistry and their pharmaceutical value are then coated with ultimate chapters natural reactions and their functions to drug discovery and improvement and average items chemistry.

* available creation to the foremost parts of chemistry required for all pharmacy measure courses
* student-friendly and written at a degree appropriate for non-chemistry scholars* comprises studying ambitions before everything of every chapter
* specializes in the actual houses and activities of drug molecules

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Additional info for Chemistry for Pharmacy Students: General, Organic and Natural Product Chemistry

Example text

Similarly, cis- and trans-cinnamic acid only differ in the three dimensional orientation of the atoms or groups. HO HO 4 HO 6 HO O HO 4 HO 5 1 3 2 OH α-Glucose OH O 6 O OH 5 3 2 OH 1 OH O β-Glucose OH cis-Cinnamic acid trans-Cinnamic acid There are two major types of stereoisomer: conformational isomers and configurational isomers. Configurational isomers include optical isomers, geometrical isomers, enantiomers and diastereomers. Conformational isomers Atoms within a molecule move relative to one another by rotation around single bonds.

Similarly, anthramycin is another antitumour drug, which binds covalently to N-2 of guanine located in the minor groove of DNA. Anthramycin has a preference for purine–G–purine sequences (purines are adenine and guanine) with bonding to the middle G. Cisplatin, an anticancer drug, is a transition metal complex, cis-diamine-dichloro-platinum. The effect of the drug is due to the ability to platinate the N-7 of guanine on the major groove site of the DNA double helix. 2 for nucleic acid structures).

Only if the two atoms have exactly the same electronegativity is a nonpolar bond formed. Electronegativity increases from left to right and bottom to top in the periodic table as shown below (electronegativity is shown in parentheses). 9 the bond is polar covalent. 0 or greater, the bond is ionic. Some examples are shown below. 4 Types of bond Polar covalent Nonpolar covalent Polar covalent Nonpolar covalent Polar covalent Electrons in a polar covalent bond are unequally shared between the two bonded atoms, which results in partial positive and negative charges.

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Chemistry for Pharmacy Students: General, Organic and Natural Product Chemistry by Satyajit Sarker, Lutfun Nahar

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