By A.T. Sumner, A.C. Chandley

ISBN-10: 9401046603

ISBN-13: 9789401046602

ISBN-10: 9401115109

ISBN-13: 9789401115100

When the overdue Professor C. D. Darlington based what built into the overseas Chromosome meetings in Oxford in 1964, he was once involved that scientists who labored on various elements of chromosomes, or who studied them in numerous methods, must have the potential of "discussing the elemental difficulties of chromosomes with one another". the truth that good over three hundred scientists with a large choice of pursuits got here to Edinburgh in August 1992 for the eleventh foreign Chromosome convention exhibits that there's nonetheless a similar want, and in addition the need between chromosomologists to have such discussions. the current quantity includes just about all the invited contributions, and attests to the variety of methods and purposes in chromosomal experiences. many years in the past it will probably have looked as if it would a few that chromosome stories have been being outmoded via molecular biology, however the molecular biologists have now discovered that they should learn about chromosomes, and certainly an immense, if ill-defined self-discipline of 'molecular cytogenetics' has grown up lately. we're happy that during making plans the convention and this publication, quite a bit of the paintings provided is on the interface among cytogenetics and molecular biology. this would definitely proceed sooner or later, as limitations among disciplines are mostly man made, and every has a lot to profit from the others.

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Extra resources for Chromosomes Today: Volume 11

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Despite anti fade agents), special optical systems have been developed for their detection and analysis. These involve cooled charged-coupled device (CCD) cameras, optical disc storage and image analysis systems. CCD cameras are extremely sensitive and the recorded signals can be analysed at leisure once they are recorded on optical disc. The use of these systems has led to the development of multicolour FISH whereby 5 or more colours can be used simultaneously to identify DNA probes in situ (Ellis et ai, pers.

1991) Identification and characterisation of the familia! adenomatous polyposis coli gene. E. et a! (1983) A polymorphic DNA marker genetically linked to Huntington's disease. Nature, 306, 234-238 Hansemann, D. (1891) Uber Pathologische Mitosen. G. et al (1992) Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy. , Ullrich, A. F. (1981) Localisation of the human insulin gene to the distal end of the short arm of chromosome 11. Proc. Nat!. Acad. Sci. , 78, 4458-4460 Harris, P.

4 The contribution of in situ hybridisation to human gene mapping In situ hybridisation was first applied to the chromosomal localisation of highly repetitive satellite DNA which mapped mainly to centromeric regions and to the short arms of acrocentric chromosomes. A. Ferguson-Smith nucleolar organiser regions in the satellite stalks of the five human acrocentric chromosomes (Henderson et ai, 1972). The first attempts to apply the method for mapping single copy genes used globin messenger RNA from rabbit reticulocytes but this was unsuccessful largely because it proved impossible to incorporate sufficient radioisotope into the RNA probe (Price et ai, 1972).

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Chromosomes Today: Volume 11 by A.T. Sumner, A.C. Chandley


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