By Bernard Weiss (auth.), Leslie L. Iversen, Susan D. Iversen, Solomon H. Snyder (eds.)

ISBN-10: 1461571782

ISBN-13: 9781461571780

ISBN-10: 1461571804

ISBN-13: 9781461571803

Volume 18 of the guide of Psychopharmacology represents the 1st of a sequence of volumes meant to carry past sections of the paintings brand new. Volumes 7, eight, and nine, released in 1977 and 1978, handled rules of habit, medications and neurotransmitters, and neuroanatomy. In next volumes devoted to those matters, a mix of subject matters might be lined in a given quantity, masking either advances in simple wisdom in those 3 components of the topic and studies of theoretical and meth­ odological matters deemed to be of specific relevance at the present. L. L. !. S. D. !. S. H. S. vii CONTENTS bankruptcy 1 habit as a degree of inauspicious Responses to Environmental Contaminants BERNARD WEISS 1. specific views 1 1. 1. Pharmacology and Toxicology . . . . . . . . . . . . . . 1 1. 2. Origins of Behavioral Toxicology . . . . . . . . . . . . 2 1. three. distinctive difficulties 2 2. particular elements . . . . . . . . . . . . . . . . . . . . . . . . . . . five 2. 1. Heavy Metals five 2. 2. risky Solvents 20 2. three. insecticides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 2. four. Air toxins 36 2. five. Nonspecific Poisons . . . . . . . . . . . . . . . . . . . . . . forty two 2. 6. nutrients ingredients forty four three. destiny customers forty seven three. 1. Chemical Waste . . . . . . . . . . . . . . . . . . . . . . . . . forty seven three. 2. weak Populations . . . . forty eight three. three. The statistics of hazard . . . . . . . . . . . . . . . . . . . . . forty nine three. four. Screening forty nine three. five. Implications for Psychopharmacology fifty one four. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . fifty one bankruptcy 2 country established studying and Drug Discriminations DONALD A. OVERTON 1. advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . fifty nine 2. Description of country based studying . . . . . . . . . . fifty nine ix x CONTENTS three. historical past of improvement of data approximately SDL 60 three. 1. 19th Century reviews. . . . . . . . . . . . . . . .

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Winneke relied on three sources of data: an auditory vigilance task, critical flicker frequency (CFF) , and a battery of psychomotor tasks. Three studies on auditory vigilance and CFF were performed with methylene chloride concentrations of 300, 500, and 800 ppm. In the fourth experiment, methylene chloride levels were set at 800 ppm to assess psychomotor function. The fifth experiment studied 50 and 100 ppm of carbon monoxide. Neither concentration of carbon monoxide produced significant changes in psychomotor performance.

They confirmed the necessity to combine variables to discriminate between exposure groups and to distinguish affected individuals. The latter consideration typically is neglected in epidemiologie studies. Mostly, they emphasize group differences, an emphasis that does not help a clinician trying to deterrnine whether the source of a complaint is occupationally related, or an industrial organization trying to insure that no individual (perhaps highly susceptible) worker has exceeded his or her idiosyncratic exposure limits .

Their measures, however, were made with a screening device, the Bausch and Lomb Ortho-Rater, which differs from the closelycontrolled laboratory devices used by the other experimenters. Impairment on tasks of coordination, at least the simpler forms, seems not to be produced by low levels of COHb. Automobile driving perform- 38 BERNARD WE ISS ance embraces many di fferent components of coordination and is an attractive experimental situation also because of its direct applicability. Rummo and Sarlanis (1974) devised a simulator requiring the subjeet to maintain a specific distance between his car and a lead car whose speed changed unpredictably.

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Drugs, Neurotransmitters, and Behavior by Bernard Weiss (auth.), Leslie L. Iversen, Susan D. Iversen, Solomon H. Snyder (eds.)


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