By Tiina P. Iismaa Ph.D., Trevor J. Biden Ph.D., John Shine Ph.D. (auth.)

ISBN-10: 3662219301

ISBN-13: 9783662219300

ISBN-10: 3662219328

ISBN-13: 9783662219324

This e-book is ready the hot advances within the structural and useful characterization of receptors that impression intracellular signalling occasions via interplay with intracellular GTP-binding proteins (G proteins). Molecular cloning of participants of the G protein-coupled receptor superfamily has complemented pharmacological investigations in offering a recognition of the structural and useful range of those receptors. An elevated realizing of the involvement of specific receptor subtypes in general and pathophysiological techniques represents interesting probabilities for the advance of hugely particular and powerful healing agents.

Show description

Read or Download G Protein-Coupled Receptors PDF

Similar nonfiction_8 books

New PDF release: Ordering at Surfaces and Interfaces: Proceedings of the

This quantity comprises the complaints of the 3rd in a chain of biennial NEC Symposia on primary techniques to New fabric stages subsidized by way of the NEC company, Tokyo, Japan. The symposium used to be held from October 7 to eleven, 1990, on the Hakone Kanko H9tel in Hakone. approximately forty invited contributors stayed jointly, grew to become interested by extreme discussions, and freely exchanged rules either out and in of the convention room, which confronted Mt.

Download e-book for kindle: Large Clusters of Atoms and Molecules by M. Brack, S. Creagh, P. Meier, S. M. Reimann, M. Seidl

Very lately it has develop into attainable to supply and signify huge clusters containing a precise, predetermined variety of atoms. via those efforts it has turn into transparent that clusters containing while many as 20,000 atoms can't but be regarded as being tiny crystals. Their constitution is frequently icosahedral.

Download PDF by Lasse B. Jenner, Adam Ben-Shem (auth.), Jonathan D. Dinman: Biophysical approaches to translational control of gene

This e-book offers a most suitable source on realizing the ribosome's crucial nature and the way it interacts with different proteins and nucleic acids to manage protein synthesis. As one of many crucial foundations in our knowing of the biology on the molecular point, this subject appeals to a large viewers, from bench researcher to clinician.

Download PDF by Nancy J. Rusch, William J. Stekiel (auth.), Robert H. Cox: Cellular and Molecular Mechanisms in Hypertension

High blood pressure is well-known to be one of many significant hazard components for the improvement of peripheral vascular disorder. the decade has witnessed a number of significant advances in remedy for high blood pressure, together with the advance of angiotensin-converting enzyme inhibitors and calcium channel blockers. those compounds have drastically enhanced the facility to regulate blood strain and to minimize the impression of this threat issue on morbidity and mortality.

Additional resources for G Protein-Coupled Receptors

Example text

218 This is a novel and versatile bioassay which not only allows functional activation of cloned receptors to be analyzed, but also represents a potential means for screening eDNA libraries to allow clones encoding new receptors to be isolated. 2. HOMOLOGY CLONING The conservation of amino acid sequence features seen among members of the G protein-coupled receptor superfamily is reflected at the DNA level and has been used for the isolation of a large number of additional members of the G protein-coupled receptor superfamily.

182 Smaller peptide ligands, on the other hand, may interact with multiple receptor domains. For example, in receptors for the tackykinin peptides substance P, neurokinin A (NKA; substance K) and neurokinin B (NKB; neuromedin K), several extracellular and TM segments contribute to the ligand binding site and in provision of determinants for receptor subtype selectivity. 183 Structural determinants for ligand binding and recognition which have been identified for a number of G proteincoupled receptors are discussed in detail in chapter 3.

The a 1B- and ~ 2 -adrenergic receptor genes are located on murine chromosomes 11 and 19, respectively, but the organization of genes linked to these loci on the murine chromosomes resembles the organization of homologous genes on human chromosome 5. Thus, while chromosomal rearrangement has occurred in the mammalian lineage leading to the mouse, linkage groups have been conserved during evolution of human and murine genomes.

Download PDF sample

G Protein-Coupled Receptors by Tiina P. Iismaa Ph.D., Trevor J. Biden Ph.D., John Shine Ph.D. (auth.)


by Edward
4.1

Rated 4.57 of 5 – based on 4 votes