By Julia M. Polak, Giorgio Terenghi (auth.), Terry W. Moody (eds.)

ISBN-10: 0306444844

ISBN-13: 9780306444845

ISBN-10: 1461528461

ISBN-13: 9781461528463

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01% Triton X-100 and re-centrifuged and the supernatant aspirated off). lM ovine Tyr-CRF. Circular dichroism spectroscopy of CRF analog I and its analogs was performed using a Jasco Model 720 Spectrometer. Molar ellipticity data for each compound was determined as a function of wavelength (178-260 nm). 1 mm cell. CRF RECEPTOR BINDING STRUCTURE-ACTIVITY RELATIONSHIPS Multiple (iterative) Ala substitution in the central domain (CRF22-31 sequence) of CRF analog I was examined by a series of compounds (II-VI) in which the Arg 23 , Glu 25 , Gln 26 , Leu 27 ,Gln 29 , and/or Gln 30 were modified.

C. , 1992, Galanin inhibits proinsulin gene expression stimulated Endocrinology, 129:1682. by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma TC-1 cells. Endocrinology, 130:2890. 22. , 1987, Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies. Proc. Natl. Acad. Sci. USA, 84:7339. 23. , 1989, Galanin receptor and its ligands in the rat hippocampus. Eur. J. Biochem. 181:269. 24. Flowe, K.

V. Pallai, M. Mabilia. Goodman. W. Vale, and J. Rivier, Structureal homology of corticotropinreleasing factor, sauvagine , and urotensin I: Circular dichroism and prediction studies. Proc. Natl. Acad. A .. 80: 6770 (1983) 21. B. DeSouza, Corticotropin-releasing factor receptors in the rat central nervous system: Characterization and regional distribution. J. Neuroscience. 7: 88 (1987). 22. -H. T. Yang, and H. Martinez. Detennination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion.

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Growth Factors, Peptides and Receptors by Julia M. Polak, Giorgio Terenghi (auth.), Terry W. Moody (eds.)

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