By R. Sousa (auth.), Prof. Dr. Fritz Eckstein, Prof. David M. J. Lilley (eds.)

ISBN-10: 3642606911

ISBN-13: 9783642606915

ISBN-10: 3642645097

ISBN-13: 9783642645099

Mechanisms of Transcription offers a different viewpoint at the basic procedures of transcription. a suite of distinct authors attracts jointly the underlying mechanisms keen on the method of transcription. This contains RNA polymerase functionality and its interplay with promoter sequences, and the constructions of some of the elements at the transcriptional equipment. either prokaryotic and eukaryotic structures, NMR and crystallographic buildings of a couple of very important eukaryotic transcription elements are mentioned, in addition to the position of chromatin structure.

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J Mol Bioi 244:6-12 Strothkamp RE, Oakley JL, Coleman JE (1980) Promoter melting by TI ribonucleic acid polymerase as detected by single-stranded endonuclease digestion. Biochemistry 19:1074-1080 Zhang X, Studier FW (1995) Isolation of transcriptionally active mutants of TI RNA polymerase that do not support phage growth. A. W. ROBERTS2, A. MALHOTRAl, M. MARR 2, K. SEVERINOVl, and E. SEVERINOVA l 1 Introduction The core RNA polymerases from bacterial and eukaryotic cells, which are homologous in structure and function (Allison et al.

1996), suggest that cr factors may be structurally organized into relatively independent domains connected by linker regions. We recently used limited proteolysis to probe the domain organization of E. coli 0"70, showing that this may indeed be the case (Severinova et al. 1996). Here, we review recent functional and structural studies focused on one of the proteolytic ally resistant 0" 70 domains containing conserved region 2, the most highly conserved region of 0" sequences (Lonetto et al. 1992).

4b) that could interact with the negatively charged phosphate backbone of the DNA. Our functional studies and other evidence described above indicate that (J conserved region 2 interacts with the nontemplate strand in the open promoter complex. 4 in the manner and orientation schematically illustrated in Fig. 5. If (J conserved region 2 functions in part as a sequence-specific singlestrand DNA binding protein, then why doesn't (J iObind single-stranded oligos containing the non-template strand -10 consensus sequence in the absence of core RNAP?

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Mechanisms of Transcription by R. Sousa (auth.), Prof. Dr. Fritz Eckstein, Prof. David M. J. Lilley (eds.)

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