By C. J. Parker (auth.), Charles J. Parker A. B., M.D. (eds.)
In this quantity a entire overview of membrane proteins that keep an eye on supplement and perforin-mediated cytolysis is gifted. a close analysisis supplied of the biochemical, molecular, and practical positive aspects of those proteins; the glycosyl phosphatidylinositol associated proteins are coated, with emphasis put on the sensible value of this sort of membrane anchor. additional chapters contain reports of the consequences of supplement activation on cells which are metabolically energetic, and of the legislation of cellphone killing through cytotoxic lymphocytes, contemplating the similarities and disparities among the supplement and perforin platforms. The healing use of recombinant CR1 for immune-mediated pathophysiological tactics is mentioned in a separate section.
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Extra info for Membrane Defenses Against Attack by Complement and Perforins
The LHRs of the A allotype have been designated A, B, C, and D types, whereas the fifth LHR of the B allotype is designated A/B because of its sequence similarity to both the A and B LHR. The C3b and C4b binding domains of CR1 have been localized to the terminal three LHR (A, B, and C) of the A allotype. These studies were facilitated by the positioning of convenient restriction sites at the boundaries of each LHR. This allowed recombinant CR1 to be investigated by selectively deleting one or more of the LHRs (KLICKSTEIN et al.
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Membrane Defenses Against Attack by Complement and Perforins by C. J. Parker (auth.), Charles J. Parker A. B., M.D. (eds.)