By C. J. Parker (auth.), Charles J. Parker A. B., M.D. (eds.)

ISBN-10: 3642770142

ISBN-13: 9783642770142

ISBN-10: 3642770169

ISBN-13: 9783642770166

In this quantity a entire overview of membrane proteins that keep an eye on supplement and perforin-mediated cytolysis is gifted. a close analysisis supplied of the biochemical, molecular, and practical positive aspects of those proteins; the glycosyl phosphatidylinositol associated proteins are coated, with emphasis put on the sensible value of this sort of membrane anchor. additional chapters contain reports of the consequences of supplement activation on cells which are metabolically energetic, and of the legislation of cellphone killing through cytotoxic lymphocytes, contemplating the similarities and disparities among the supplement and perforin platforms. The healing use of recombinant CR1 for immune-mediated pathophysiological tactics is mentioned in a separate section.

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Extra info for Membrane Defenses Against Attack by Complement and Perforins

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The LHRs of the A allotype have been designated A, B, C, and D types, whereas the fifth LHR of the B allotype is designated A/B because of its sequence similarity to both the A and B LHR. The C3b and C4b binding domains of CR1 have been localized to the terminal three LHR (A, B, and C) of the A allotype. These studies were facilitated by the positioning of convenient restriction sites at the boundaries of each LHR. This allowed recombinant CR1 to be investigated by selectively deleting one or more of the LHRs (KLICKSTEIN et al.

Immunol Today 7: 230-234 Rey-Campos J, Rubinstein P, Rodriguez de Cordoba S (1987) Decay-accelerating factor. Genetic polymorphism and linkage to the RCA (regulator of complement activation) gene cluster in humans. J Exp Med 166: 246-252 Rhee SG, Suh PG, Ryu SH, Lee SY (1989) Studies of inositol phospholipid-specific phospholipase C. Science 244: 546-550 Rimoldi MT, Sher A, Heiny S, Lituchy A, Hammer CH, Joiner K (1988) Developmentally regulated expression by Trypanosoma cruz; of molecules that accelerate the decay of complement C3 convertases.

Proc Nail Acad Sci USA 80: 5430-5434 Pearce EJ, Hall BF, Sher A (1990) Host-specific evasion of the alternative complement pathway by schistosomes correlates with the presence of a phospholipase C- sensitive surface molecule resembling human decay accelerating factor. J Immunol144: 2751-2756 Perkins SJ, Haris PI, Sim RB, Chapman 0 (1988) A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods. Biochemistry 27: 4004-4012 Post TW, Arce MA, Liszewski MK, Thompson ES, Atkinson JP, Lublin OM (1990) Structure of the gene for human complement protein decay accelerating factor.

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Membrane Defenses Against Attack by Complement and Perforins by C. J. Parker (auth.), Charles J. Parker A. B., M.D. (eds.)


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