By H. L. Fields (auth.), Professor Dr. med. Albert Herz, Dr. med. Huda Akil, Dr. med. Eric J. Simon (eds.)

ISBN-10: 3642775403

ISBN-13: 9783642775406

ISBN-10: 364277542X

ISBN-13: 9783642775420

In 1957 Otto SCHAUMANN, one of many pionieers in pharmacological study on morphine and the 1st to organize artificial opiates, awarded a mono­ graph entitled "Morphin und morphiniihnliche Verbindungen" as quantity 12 of the instruction manual of Experimental Pharmacology. Now, 35 years later, we're publishing within the similar sequence a brand new accomplished quantity masking the current prestige of opioid examine. considering that point the subject has improved greatly. The id of opioid receptors and the detection in their endogenous ligands have been landmarks which opened a brand new period in opioid examine and fertilized the total box of neurobiology. The quick advance­ ment of this box is illustrated within the determine, which represents the variety of papers released on opioid study on the grounds that 1970 (searches played at the MEDLINE info base). 3000

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It is important to point out that opioids inhibit. pain transmission neurons directly as well as indirectly, through pain-modulating systems. Direct inhibition of neurons that are part of the nociceptive transmission pathway is most clearly operative at the spinal level, where opioids reduce transmitter release from primary afferent neurons and directly hyperpolarize nociceptive dorsal horn neurons (see Chaps. 29 and 30, part I of this volume). Similar direct actions by opioids could inhibit supraspinal nociceptive transmission neurons at thalamic and cortical levels.

2. Nalbuphine......................................... 3. Butorphanol ........................................ III. Partial Agonist Drugs .................................. 1. Buprenorphine............................... . . .. IV. Pure Antagonist Drugs ................................. 1. Naloxone Hydrochloride ............................. F. Pharmacodynamic and Pharamacokinetic Studies of Opioid Analgesics. . . . . . . . . . . . . . . . . . . . I. Pharmacodynamic and Pharmacokinetic Models.

I. Acute administration of periaqueductal and periventricular sites. II. Chronic self-administration in the periventricular gray matter. J Neurosurg 47:184-194 Rogers RJ (1977) Elevation of aversive threshold in rats by intra-amygdaloid injection of morphine sulfate. Pharmacol Biochem Behav 6:385-390 Ruda MA (1988) Spinal dorsal horn circuitry involved in the brain stem control of nociception. Prog Brain Res 77:129-140 Sakuma Y, Pfaff DW (1980) Convergent effects of lordosis relevant somatosensory and hypothalamic influences on central gray cells in the rat mesencephalon.

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Opioids II by H. L. Fields (auth.), Professor Dr. med. Albert Herz, Dr. med. Huda Akil, Dr. med. Eric J. Simon (eds.)

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