By Chris Knipe, W. E. Watts

ISBN-10: 0471899356

ISBN-13: 9780471899358

Comprises such mechanisms as addition and removal reactions, nucleophilic and electrophilic fragrant substitutions, and molecular rearrangements. * every one bankruptcy offers with particular response varieties, reviewing the former year's advancements within the quarter. * greatly referenced to prior volumes and first journals.

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G. 7 Their hemiacetal derivatives have been studied by 31 P-NMR in the presence of alcohols, for the representative acetyl and benzoyl compounds (5; R ˆ Me, Ph). Equilibrium and 1 Reactions of Aldehydes and Ketones and their Derivatives 3 forward and reverse rate constants have been measured. These results, and a separation of the enthalpic and entropic contributions, suggest a substantially reactant-like transition state. The contribution of the PO(OMe)2 group to the reactivity is underlined by an MNDO calculation of s* ˆ 2:65 for this moiety.

The factors that contribute to producing the later transition state in enzymes are discussed. 153 The strategy involves varying the nature of the lithium amide substituents to bias protonation towards (E)- or (Z)-enolate. Combinations of phenyl, trimethylsilyl, and alkyl groups of varying bulk were employed. g. using lithium N-t-butyl(trimethylsilyl)amide], while high Zyield requires two electron-withdrawing groups, as in the case of the N-(trimethylsilyl)anilide base; both of these modi®ed forms of LDA should be of considerable synthetic utility.

15 by 1 H-NMR. Hydroxyacetal (10a) exists mainly in a boat±chair conformation (boat cycloheptanol ring), whereas the methyl derivative (10b) is chair±boat,13 as shown by 1 H-NMR, supported by molecular mechanics calculations. 4 Organic Reaction Mechanisms 1997 Reactions of Glucosides and Nucleosides A number of fundamental studies of the nature of the anomeric effect have been undertaken, probed via kinetics and exo-=endo-regioselectivities. 14 In both series, the most electronegative substituent (methoxy) is associated with the fast rates, and the least electronegative (acetamido) is the slowest.

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Organic reaction mechanisms 1998 - an annual survey covering the literature dated December 1997 to November 1999 by Chris Knipe, W. E. Watts


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