By Michael E. Aulton BPharm PhD FAAPS MRPharmS, Kevin Taylor

ISBN-10: 0443055173

ISBN-13: 9780443055171

A finished textbook overlaying the layout of dosage types and all features of drug supply structures. 'Pharmaceutics' in its broadest feel is the 'art of the apothecary' or, in basic terms, pharmaceutical arrangements. It is still a various topic within the pharmacy curriculum, encompassing layout of substances, their manufacture, and the removal of micro-organisms from the goods. This books encompasses all these components and will pay specific realization to the layout of dosage varieties and their manufacture.

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43 SCIENTIFIC PRINCIPLES OF DOSAGE FORM DESIGN where C is concentration, N is Avogadro's number, V is the hydrodynamic volume of each molecule and M is the molecular mass. However, it does suffer from the obvious disadvantage that the assumption is made that all polymeric molecules form spheres in solution. 2. Its value gives an indication of the interaction between the polymer and the solvent, such that a positive slope is produced for a polymer that interacts weakly with the solvent, and the slope becomes less positive as the interaction increases.

Recently, renewed interest has been shown in filling semisolid and microemulsion formulations into hard gelatin capsules to provide rapidly dispersing dosage forms for poorly soluble drugs. Suspensions, which contain finely divided drugs suspended in a suitable vehicle, are a useful means of administering large amounts of drugs that would be inconvenient if taken in tablet or capsule form. They are also useful for patients who experience difficulty in swallowing tablets and capsules, and for paediatric SCIENTIFIC PRINCIPLES OF DOSAGE FORM DESIGN Lattice theories postulate that liquids have crystalline or quasicrystalline structures.

The only upper limit on the volume used is that it should not block the ventilating tube Z. The viscometer is clamped vertically in a constant-temperature water bath and allowed to attain the required temperature. Tube W is then closed and tube Z opened so that liquid can be drawn away from the bottom of the capillary. Tube W is then opened and the time the fluid takes to fall between marks E and F is recorded. If at any time during the determination the end of the ventilating tube Z becomes blocked by the liquid, the experiment must be repeated.

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Pharmaceutics: The Science of Dosage Form Design by Michael E. Aulton BPharm PhD FAAPS MRPharmS, Kevin Taylor


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