By H. Schmidt-Traub

ISBN-10: 3527306439

ISBN-13: 9783527306435

This interdisciplinary method combines the chemistry and engineering concerned to explain the belief and development of chromatographic procedures. The e-book covers contemporary advancements in preparative chromatographic approaches for the separation of "smaller" molecules utilizing typical laboratory gear in addition to the exact perception of commercial chemical vegetation.

Following an introductory part at the historical past of chromatography, the present nation of analysis and the layout of chromatographic techniques, the e-book is going directly to outline the overall terminology. There then stick to sections on strong fabrics and packed columns approach suggestions. ultimate chapters on modeling and resolution of version parameters, the layout and optimization of preparative chromatographic tactics and chromatographic reactors permit for the optimal choice of chromatographic structures.

crucial for chemists and engineers operating within the chemical substances and pharmaceutical industries in addition to for foodstuff applied sciences, because of the interdisciplinary nature of those techniques.

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Additional resources for Preparative Chromatography. of Fine Chemicals and Pharmaceutical Agents

Example text

This step can follow two different transport mechanisms, which can occur separately or parallel to each other: pore diffusion (3a) and surface diffusion (3b). If mass transport occurs by surface diffusion (3b) a solute molecule is adsorbed and transported deeper into the pore system by movement along the pore surface. During the whole transport process, molecules are within the attraction forces of the adsorbent surface. Notably, the attractive forces between the surface and absorbed molecules are so strong (Zhang et al, 2003) that, for many common adsorpt–adsorbent systems encountered in preparative chromatography, surface diffusion is physically implausible (especially in charged adsorpt – charged surface interactions).

3 Fluid Dynamics Fig. 8 Band broadening in a column due to axial dispersion. V dance with the band broadening the maximum concentration of the solute is decreased. This results in an unfavorable dilution of the target component fraction. The main factors that influence axial dispersion are discussed below. 1 Extra Column Effects Every centimeter of tubing, as well as any detector, between the point of solute injection and the point of fraction withdrawal contributes to the axial dispersion of the samples and thus decreases the concentration and separation efficiency.

Examples for the 7 8 1 Introduction scale-up of an optimized plant are also given. Subsequently, methods for the modelbased design and optimization of batch and SMB (Simulated Moving Bed) processes are introduced. For this purpose dynamic simulations of an experimentally validated model are used. Especially in the design and optimization of the complex SMB processes, a quick design and optimization method for SMB will be introduced. Finally, the performance of batch and SMB processes are compared.

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Preparative Chromatography. of Fine Chemicals and Pharmaceutical Agents by H. Schmidt-Traub


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