By R. Fernandez
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Wang HE, Shapiro NI, Angus DC, Yealy DM. National estimates of severe sepsis in United States emergency departments. Crit Care Med. 2007; 35 (8):1928-36. Zaragoza R, Artero A, Camarena JJ, Sancho S, González R, Nogueira JM. The influence of inadequate empirical antimicrobial treatment on patients with bloodstream infections in an intensive care unit. Clin Microbiol Infect 2003; 9 (5):1-7. Part 2 Etiology 2 Septic Shock by Gram-Negative Infections: Role of Outer Membrane Proteins Marilena Galdiero1, Marco Cantisani2, Rossella Tarallo2, Annarita Falanga2 and Stefania Galdiero2 1Second 2University University of Naples, Naples of Naples “Federico II”, Naples Italy 1.
Crit Care Med 2008; 36 (1):296-327. Diekema DJ, Pfaller MA, Jones RN,& SENTRY Participants Group.. Age-related trends in pathogen frequency and antimicrobial susceptibility of bloodstream isolates in North America: SENTRY Antimicrobial Surveillance Program, 1997–2000. Int J Antimicrob Agents 2002; 20 (6): 412–418. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL: Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003. Crit Care Med 2007; 35 (5):1244 –1250.
Men have a higher prevalence of severe sepsis and septic shock than women. The fact that this lower rate of sepsis syndromes observed in women is present over all range of age argues against the gender differences being solely mediated through sex hormones. Respiratory infections are the major source of severe sepsis and septic shock, which is more prevalent in men than in women, followed by intra-abdominal infections, urinary tract infections and primary bloodstream infections. Respiratory infections and abdominal infections appear to have a worse prognosis than other foci.
Severe Sepsis and Septic Shock - Understanding a Serious Killer by R. Fernandez