By Koichi Tanaka

ISBN-10: 3527306129

ISBN-13: 9783527306121

Nowadays, with Google and technological know-how Finder student, you might imagine that medical books have gotten out of date. whereas this can be actual every so often, it truly is under no circumstances actual for the "Solvent-Free natural Synthesis". This significant e-book is a testomony to the good fortune of the solvent-free reactions, that are one of many cornerstones of eco-friendly chemistry. by way of abolishing using solvents, a lot of that are quite often poisonous, the reactions turn into extra environmentally pleasant and therefore "green". The reactions that are lined usually supply first-class yields and excessive purity of the goods. The most powerful characteristic of the publication is that it offers brief preps for numerous solid-state syntheses. those preps were extracted from numerous journals that are quoted, on the way to lookup the unique references. the fashion of this e-book is similar to the vintage e-book through Hickinbottom ("Reactions of natural Compounds").
I have in comparison a number of brief preps to the experimental sections of the unique papers and feature discovered that the writer certainly has extracted the simplest from the papers. furthermore, my scholars have performed a number of of those reactions with solid luck. The association of the ebook is by means of the kind of the natural reactions. There are 15 chapters, that are dedicated to the discounts, oxidations, bond formations among carbon- carbon, carbon-oxygen, carbon-sulfur, carbon-phosphorous, carbon-halogen, nitrogen-nitrogen and nitrogen-sulfur, and numerous response varieties, similar to rearrangements, eliminations, protections, deprotections, polymerizations, and supramolecular complexations. all of the response equations are proven in transparent portraits and with notations that have the elemental response stipulations. i like to recommend this booklet such a lot enthusiastically, for teachers and complicated students.

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1 Cationic/Cationic Processes AcO H H AcO O O O OAc HO 60% 1-33 1-32 O O O HO 65% AcO OAc AcO 1-35 1-34 O tBuO O O H H O O 60% O O OAc O 1-37 1-36 O O tBuO O O 75% O OAc O O O 1-38 1-39 Reaction conditions: 1 eq BF3•OEt2, CH2Cl2, –40 °C, 10–30 min, H2O quench; then Ac2O, Et2N, CH2Cl2. 10. Synthesis of oxepanes. spectively. 1. 11) [11]. 12). The conformation 1-45, which would lead to 1-46 seems to be disfavored. The tetrahydropyran moiety, another oxacycle, is also found in many biologically active natural products from marine and terrestrial origin.

12 For excellent reviews, see: (a) T. L. B. Boivin, Tetrahedron 1987, 43, 3309−3362; (b) M. C. Elliott, J. Chem. Soc. Perkin Trans. 1 2000, 1291−1318. 13 I. E. -M. Plancher, Tetrahedron Lett. 1999, 40, 5259−5262. 14 B. Leroy, I. E. Markó, J. Org. Chem. 2002, 67, 8744−8752. -P. -C. -Y. Yang, Synthesis 2002, 7, 937−940. -P. -Y. -T. Ma, J. Am. Chem. Soc. P. -T. -Y. Hu, Int. Ed. Engl. Angew. Chem. 2001, 40, 2921−2922. 17 For a excellent review, see: H. N. C. -Y. -W. -C. Yip, J. Tanko, T. Hudlicky, Chem.

Johnson, L. E. Overman, Tetrahedron Lett. 1991, 32, 7361−7364. 6 L. E. Overman, J. P. Wolfe, J. Org. Chem. 2002, 67, 6421−6429. 7 (a) J. K. -H. Hui, J. L. McLaughlin, J. Nat. Prod. 1990, 53, 237− 278; (b) U. Koert, Tetrahedron Lett. 1994, 35, 2517−2520; (c) T. R. Hoye, P. R. Hanson, Tetrahedron Lett. -C. Harmange, B. Figadere, Tetrahedron Lett. 1993, 34, 8093−8096. 8 (a) U. Koert, M. Stein, K. Harms, Tetrahedron Lett. 1993, 34, 2299−2302; (b) U. Koert, H. Wagner, U. Pidun, Chem. Ber. 1994, 127, 1447−1457.

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Solvent-free Organic Synthesis (Green chemistry) by Koichi Tanaka


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